The Role of Matrix Protein 2 Ectodomain in the Development of Universal Influenza Vaccines
Identifieur interne : 000273 ( Main/Exploration ); précédent : 000272; suivant : 000274The Role of Matrix Protein 2 Ectodomain in the Development of Universal Influenza Vaccines
Auteurs : Xavier Saelens [Belgique]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps antiviraux (usage thérapeutique), Anticorps monoclonaux (immunologie), Anticorps monoclonaux (usage thérapeutique), Antigènes viraux (immunologie), Cadres ouverts de lecture, Domaines protéiques (immunologie), Grippe humaine (), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Immunoglobuline G (immunologie), Immunoglobuline G (usage thérapeutique), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (virologie), Pandémies (), Protéines de la matrice virale (), Protéines de la matrice virale (génétique), Protéines de la matrice virale (immunologie), Récepteurs du fragment Fc des IgG (immunologie), Souris, Sous-type H3N2 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (isolement et purification), Vaccins antigrippaux (immunologie).
- MESH :
- génétique : Protéines de la matrice virale.
- immunologie : Anticorps antiviraux, Anticorps monoclonaux, Antigènes viraux, Domaines protéiques, Immunoglobuline G, Infections à Orthomyxoviridae, Protéines de la matrice virale, Récepteurs du fragment Fc des IgG, Sous-type H3N2 du virus de la grippe A, Vaccins antigrippaux.
- isolement et purification : Sous-type H3N2 du virus de la grippe A.
- usage thérapeutique : Anticorps antiviraux, Anticorps monoclonaux, Immunoglobuline G.
- virologie : Grippe humaine, Infections à Orthomyxoviridae.
- épidémiologie : Grippe humaine.
- Animaux, Cadres ouverts de lecture, Grippe humaine, Humains, Pandémies, Protéines de la matrice virale, Souris.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (immunology), Antibodies, Monoclonal (therapeutic use), Antibodies, Viral (immunology), Antibodies, Viral (therapeutic use), Antigens, Viral (immunology), Humans, Immunoglobulin G (immunology), Immunoglobulin G (therapeutic use), Influenza A Virus, H3N2 Subtype (immunology), Influenza A Virus, H3N2 Subtype (isolation & purification), Influenza Vaccines (immunology), Influenza, Human (epidemiology), Influenza, Human (prevention & control), Influenza, Human (virology), Mice, Open Reading Frames, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (virology), Pandemics (prevention & control), Protein Domains (immunology), Receptors, IgG (immunology), Viral Matrix Proteins (chemistry), Viral Matrix Proteins (genetics), Viral Matrix Proteins (immunology).
- MESH :
- chemical , chemistry : Viral Matrix Proteins.
- chemical , genetics : Viral Matrix Proteins.
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Viral, Antigens, Viral, Immunoglobulin G, Influenza Vaccines, Receptors, IgG, Viral Matrix Proteins.
- chemical , therapeutic use : Antibodies, Monoclonal, Antibodies, Viral, Immunoglobulin G.
- epidemiology : Influenza, Human.
- immunology : Influenza A Virus, H3N2 Subtype, Orthomyxoviridae Infections, Protein Domains.
- isolation & purification : Influenza A Virus, H3N2 Subtype.
- prevention & control : Influenza, Human, Pandemics.
- virology : Influenza, Human, Orthomyxoviridae Infections.
- Animals, Humans, Mice, Open Reading Frames.
Abstract
The influenza A virus matrix protein 2 ectodomain (M2e) is a universal influenza A vaccine candidate. Numerous studies in laboratory mice, but very few in natural influenza A virus hosts, have demonstrated that M2e-based vaccines can provide protection against any influenza A virus challenge. M2e-based immunity is largely accomplished by IgG and early stage clinical studies have demonstrated that the vaccine is safe. Yet M2e is considered a difficult target to develop as a vaccine: it does not offer sterilizing immunity and its mode of action relies on Fcγ receptor-mediated effector mechanisms, most likely in concert with alveolar macrophages. In a human challenge study with an H3N2 virus, treatment with a monoclonal M2e-specific human IgG was associated with a faster recovery compared to placebo treatment. If the universal influenza vaccine field incorporates this antigen into next generation vaccines, M2e could prove its merit when the next influenza pandemic strikes.
Url:
DOI: 10.1093/infdis/jiz003
PubMed: 30715367
PubMed Central: 6452325
Affiliations:
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Le document en format XML
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(chemistry)</term><term>Viral Matrix Proteins (genetics)</term><term>Viral Matrix Proteins (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (immunologie)</term><term>Anticorps antiviraux (usage thérapeutique)</term><term>Anticorps monoclonaux (immunologie)</term><term>Anticorps monoclonaux (usage thérapeutique)</term><term>Antigènes viraux (immunologie)</term><term>Cadres ouverts de lecture</term><term>Domaines protéiques (immunologie)</term><term>Grippe humaine ()</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Immunoglobuline G (immunologie)</term><term>Immunoglobuline G (usage thérapeutique)</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Infections à Orthomyxoviridae (virologie)</term><term>Pandémies ()</term><term>Protéines de la matrice virale ()</term><term>Protéines de la matrice virale (génétique)</term><term>Protéines de la 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Viral</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines de la matrice virale</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps monoclonaux</term><term>Antigènes viraux</term><term>Domaines protéiques</term><term>Immunoglobuline G</term><term>Infections à Orthomyxoviridae</term><term>Protéines de la matrice virale</term><term>Récepteurs du fragment Fc des IgG</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term><term>Orthomyxoviridae Infections</term><term>Protein Domains</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H3N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term><term>Pandemics</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps monoclonaux</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Mice</term><term>Open Reading Frames</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cadres ouverts de lecture</term><term>Grippe humaine</term><term>Humains</term><term>Pandémies</term><term>Protéines de la matrice virale</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>The influenza A virus matrix protein 2 ectodomain (M2e) is a universal influenza A vaccine candidate. Numerous studies in laboratory mice, but very few in natural influenza A virus hosts, have demonstrated that M2e-based vaccines can provide protection against any influenza A virus challenge. M2e-based immunity is largely accomplished by IgG and early stage clinical studies have demonstrated that the vaccine is safe. Yet M2e is considered a difficult target to develop as a vaccine: it does not offer sterilizing immunity and its mode of action relies on Fcγ receptor-mediated effector mechanisms, most likely in concert with alveolar macrophages. In a human challenge study with an H3N2 virus, treatment with a monoclonal M2e-specific human IgG was associated with a faster recovery compared to placebo treatment. If the universal influenza vaccine field incorporates this antigen into next generation vaccines, M2e could prove its merit when the next influenza pandemic strikes.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lamb, Ra" uniqKey="Lamb R">RA Lamb</name></author><author><name sortKey="Lai, Cj" uniqKey="Lai C">CJ Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pinto, Lh" uniqKey="Pinto L">LH Pinto</name></author><author><name sortKey="Holsinger, Lj" uniqKey="Holsinger L">LJ Holsinger</name></author><author><name sortKey="Lamb, Ra" uniqKey="Lamb R">RA Lamb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stauffer, S" uniqKey="Stauffer S">S Stauffer</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name></author><author><name sortKey="Nebioglu, F" uniqKey="Nebioglu F">F Nebioglu</name></author><author><name sortKey="Heilig, R" 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Higgins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramos, El" uniqKey="Ramos E">EL Ramos</name></author><author><name sortKey="Mitcham, Jl" uniqKey="Mitcham J">JL Mitcham</name></author><author><name sortKey="Koller, Td" uniqKey="Koller T">TD Koller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsybalova, Lm" uniqKey="Tsybalova L">LM Tsybalova</name></author><author><name sortKey="Stepanova, La" uniqKey="Stepanova L">LA Stepanova</name></author><author><name sortKey="Kuprianov, Vv" uniqKey="Kuprianov V">VV Kuprianov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hart, Tk" uniqKey="Hart T">TK Hart</name></author><author><name sortKey="Cook, Rm" uniqKey="Cook R">RM Cook</name></author><author><name sortKey="Zia Amirhosseini, P" uniqKey="Zia Amirhosseini P">P Zia-Amirhosseini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Langley, Jm" uniqKey="Langley J">JM Langley</name></author><author><name sortKey="Macdonald, Ld" uniqKey="Macdonald L">LD MacDonald</name></author><author><name sortKey="Weir, Gm" uniqKey="Weir G">GM Weir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Didierlaurent, Am" uniqKey="Didierlaurent A">AM Didierlaurent</name></author><author><name sortKey="Laupeze, B" uniqKey="Laupeze B">B Laupèze</name></author><author><name sortKey="Di Pasquale, A" uniqKey="Di Pasquale A">A Di Pasquale</name></author><author><name sortKey="Hergli, N" uniqKey="Hergli N">N Hergli</name></author><author><name sortKey="Collignon, C" uniqKey="Collignon C">C Collignon</name></author><author><name sortKey="Garcon, N" uniqKey="Garcon N">N Garçon</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Belgique</li></country><region><li>Province de Flandre-Orientale</li><li>Région flamande</li></region><settlement><li>Gand</li></settlement><orgName><li>Université de Gand</li></orgName></list><tree><country name="Belgique"><region name="Région flamande"><name sortKey="Saelens, Xavier" sort="Saelens, Xavier" uniqKey="Saelens X" first="Xavier" last="Saelens">Xavier Saelens</name></region><name sortKey="Saelens, Xavier" sort="Saelens, Xavier" uniqKey="Saelens X" first="Xavier" last="Saelens">Xavier Saelens</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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